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KMID : 1039220180280010051
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Journal of Korean Society of Occupational and Environmental Hygiene
2018 Volume.28 No. 1 p.51 ~ p.60
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A Comparison of Dose-Response Assessments for CMR Materials in the Workpl
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Lee Kyung-Hwa
Choi Han-Young
Kim Chi-Nyon
Roh Young-Man
Choi Hee-Jin
Park Chae-Ri
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Abstract
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Objectives: Currently, there is only limited knowledge regarding the hazard of low-level exposure to CMR materials in workplaces. To overcome this limitation, a reference concentration for workers(RfCw) from among the risk assessment tools proposed by the US EPA is widely used to set a provisional workplace exposure level(PWEL) for CMR materials for which there are no established Korea Occupational Exposure Limits(KOELs) or subjective chemicals for work environment measurements as regulated by Korea Ministry of Employment and Labor(KMOEL). A simple European calculator of derived no effect level(SECO-DNEL) as proposed by REACH can also be used in place of RfCw to set the PWEL for chemicals. This study was performed to test the acceptability of using SECO-DNEL as an alternative to RfCw when setting a PWEL for low-level exposures.
Methods: The RfCw and DNEL for the five CMR materials of dinitrogen oxide, catechol, 2-phenoxy ethanol, carbitol, and carbon black were calculated using the dose-response assessments of the US EPA for RfCw and REACH guidance for SECO-DNEL, respectively. They were compared using paired t-tests to determine the statistical differences between them.
Results: For the five chemicals, the RfCw were 2.53 ppm, 0.10 ppm, 1.73 ppm, 1.66 ppm, and 0.05 mg/㎥, respectively, while the SECO-DNEL were 2.01 ppm, 0.11 ppm, 1.83 ppm, 1.77 ppm, 0.14 mg/㎥, respectively. There was no statistically significant difference between RfCw and SECO-DNEL.
Conclusions: This study suggests that the SECO-DNEL could be applied in place of RfCw to set a PWEL for low-level exposure to chemicals, especially CMR materials. To further ensure the reliability of SECO-DNEL as an alternative tool, more chemicals should be applied for calculation and comparison with RfCw.
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KEYWORD
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CMR, dose-response, OEL, REACH, RfCw, SECO-DNEL
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